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KMID : 0613820110210060912
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Journal of Life Science
2011 Volume.21 No. 6 p.912 ~ p.922
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Review of Cancer-Testis (CT) Genes
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Kim Mi-hee
Song Myung-Ha
Lee Sang-Yull
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Abstract
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Cancer-testis (CT) antigens are immunogenic protein antigens with restricted expression in the testes and a wide range of human tumor types, eliciting both humoral and cellular immune responses in cancer patients. They are considered to be ideal targets for vaccine-based immunotherapy, and more than 100 CT antigens, including MAGE, NY-ESO-1, GAGE, BAGE, LAGE, SSX2 and NY-SAR-35 have been identified to date. The CT antigens were identified through various techniques and can be divided in those that are encoded on the X chromosome, the CT-X genes, and those that are not, the non-X-CT genes. CT genes are aberrantly activated and expressed in a proportion of various types of human cancers. The biological role of CT-X in both germ line tissues and tumors remains poorly understood. Cancer vaccine trials based on several CT antigens are currently ongoing. This paper reviews recent advances in and future trends of CT antigens for cancer immunotherapy.
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KEYWORD
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Cancer-testis gene, cancer vaccine, immunotherapy, SEREX
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